NPN: 80077803

Gives your body essential nutrition and helps maintain the body's ability to metabolize nutrients.

This multivitamin/mineral is essential for those undergoing weight loss to support overall health as it provides oxygen and energy to cells for optimal function. It ensures the prevention of nutritional deficiencies, that can sometimes accompany a calorie reduced diet. Foundation Multi gives the body essential nutrition, it also includes chromium to support healthy blood glucose levels. Finally, it includes iodine to help maintain a healthy thyroid, the gland responsible for metabolism and preventing the accumulation of body fat.

PRODUCT MONOGRAPH FOR HERBAL MAGIC
Foundation Multi NPN 80077803

GENERAL INFORMATION
Herbal Magic’s Foundation Multi is a multi-vitamin/mineral formula which contains a blend of vitamins and minerals designed to help meet the nutritional needs of today. Vitamins by definition are dietary substances required for good health and normal development, by regulating metabolism and assisting in all biochemical processes in the body. Their functions can be quite complex wherein any particular vitamin may have various metabolic and chemical roles. Minerals, like vitamins, act as co-enzymes enabling the body to perform its functions including energy production, growth and healing.

Foundation Multi is a fundamental comprehensive multi-vitamin/mineral designed to fill potential nutritional gaps and support successful weight management.

This daily multivitamin helps to:

Ensure the body is functioning optimally

Ensure optimal intake of nutrients to prevent nutritional deficiencies

Maintain optimal blood sugar control to prevent hunger and even out appetite

RECOMMENDED USES
Primary Uses: Helps to maintain good health and maintain the body's ability to metabolize nutrients as well as giving the body essential nutrition.

MECHANISM OF ACTION
Research Suggests
Beta-Carotene
Beta-Carotene is a source of vitamin A that helps to maintain eyesight, skin, membranes, and immune function¹. Research suggests that beta-carotene has variety of functions to prevent certain cancers, heart disease, cataracts and age related macular degeneration. ^2,3

Biotin
Biotin is a water-soluble vitamin that plays an essential role in maintaining metabolic homeostasis. Biotin acts as a cofactor in gluconeogenesis, fatty acid synthesis and amino acid catabolism. ^4,5,6

Calcium
Calcium is the most common mineral in the body and plays a key role in a wide range of biologic functions. Calcium has an important role in building stronger and denser bones, and is also involved in neurotransmitter release and muscle contraction.⁷ Adequate calcium and vitamin D, with regular physical activity, help to achieve strong bones and may reduce the risk of osteoporosis.⁸

Calcium is well recognized to play an important role in modulating chronic disease risk.⁹ Many studies have identified strong inverse correlations between adiposity, body weight, and calcium intake, recommending calcium supplementation with weight loss or weight control programs.^10,11

Chromium
Chromium is an essential trace element and it is necessary for the efficient metabolism of carbohydrates, lipids and protein in the body. ^12,13 Chromium has been shown to be useful in its ability to support insulin, thereby assisting in healthy glucose metabolism. It is thought that chromium potentiates the action of insulin by increasing receptor numbers and increasing insulin binding to cells.¹⁴ Chromium deficiency may lead to health problems such as insulin resistance, elevated blood glucose levels, and increased risk for cardiovascular conditions and diabetes mellitus. ^12,13

Copper
Copper is an essential trace metal that plays an integral part in numerous critical enzyme processes affecting vital biological systems. Copper helps to produce and repair connective tissue, and aids in formation of red blood cells. ^15,16

Folic acid
Folate, also known as folic acid, plays a vital role in DNA synthesis and amino acid metabolism. Folic acid is important for normal brain functions and cognition.c^17,18 Research suggests that supplementation of multivitamins containing folic acid during pre-pregnancy and pregnancy is associated with reduced risk of neural tube defects and preeclampsia. ^19,20 Also, Folic acid is important for normal fetal brain function and cognition.²¹

Iodine
Iodine is the trace element that has the greatest influence on thyroid function. Iodine is an integral constituent of thyroid hormones and is required for thyroid hormone homeostasis. Thyroid hormones are necessary for human life and proper thyroid status also depends on many trace elements. The thyroid produces hormones that affect the body's metabolism and energy level. ^22,23,24,25

Magnesium
Magnesium is critical to normal human homeostasis playing many roles in energy metabolism: as an enzyme cofactor, in electrolyte balance, and in the maintenance of the properties of various cell membranes. As one of the four most abundant cations in the body, magnesium is present in more than 300 enzymatic systems. ^29,30 Magnesium helps the body to metabolize carbohydrates, fats and proteins. Magnesium also plays an important role in maintaining muscle function and in the absorption of calcium. ^29,30

Manganese
Manganese is an essential trace nutrient that plays a role in various physiological processes. Manganese is required for the regulation of carbohydrate and lipid metabolism, reproduction and normal brain function. Manganese is also an important co-factor in the brain for several enzymes, such as the antioxidant enzyme superoxide dismutase and is involved in neurotransmitter synthesis and metabolism.³¹ Manganese may also affect thyroid hormone homeostasis.³²

Molybdenum
Molybdenum is considered an essential element in the human body. It is crucial for the functioning of several enzymes including sulfite oxidase, xanthine oxidase, and aldehyde oxidase.³³

Niacinamide
Niacinamide is an essential organic compound for metabolism, essential for energy production from carbohydrates, fatty acids, and amino acids.³⁴ Niacinamide is necessary for a variety of diverse biological processes including energy production and acts as an antioxidant.³⁵

Pantothenic acid
Pantothenic acid is involved in the metabolism of carbohydrates, proteins and lipids and is a component of coenzyme A, a molecule necessary for many vital chemical reactions to occur in cells.^{36, 37}

Riboflavin
Riboflavin is a water-soluble vitamin, important for human metabolism, protecting against cancer and cardiovascular disease. The body requires more riboflavin in cases of increased metabolic demand such as during weight loss or in periods of high stress. In such cases, the supply may be rapidly depleted so it is important to ensure frequent and sufficient replenishing of this essential vitamin. ^38,39

Selenium
The essential micronutrient selenium plays an important role in maintaining the equilibrium of a healthy organism, affecting optimal endocrine and immune function, and moderating the inflammatory response. Selenium exerts its biological effects mainly through enzymatically active selenoproteins which provide protection against lipid peroxidation, support thyroid hormone metabolism, T cell immunity and modulation of the inflammatory response.^40,41 Research findings link low selenium status to neurodegenerative and cardiovascular diseases.^42,43 Additionally, selenium may also support cardiovascular health by reducing the oxidation of LDL (“bad”) cholesterol in the body.

Thiamine
Thiamine is a water-soluble vitamin, essential in metabolic energy production and the metabolism of fats, carbohydrates and proteins. As humans are unable to synthesize thiamine, this vitamin must be obtained from exogenously. The body requires more thiamine in cases of increased metabolic demand such as weight loss. In such cases, the supply may be rapidly depleted so it is important to ensure frequent and adequate supply of this essential vitamin. ^44,45

Vitamin B6
Vitamin B6 acts as cofactor in more than 140 different enzyme reactions and has critical functions in cellular metabolism and stress responses. It is a potent antioxidant that effectively quenches reactive oxygen species and is thus of high importance for cellular health. ^46,47,48

Vitamin B12
Vitamin B12 aids in the formation and regeneration of red blood cells, thereby preventing anemia. Vitamin B12 promotes growth and is essential for the maintenance of a healthy nervous system. Vitamin B12 supports normal DNA synthesis, promotes growth⁴⁹, and also assists in the proper utilization of fats, carbohydrates and proteins. ^36,50 Evidence suggests that methylcobalamin is absorbed more efficiently than the other co-enzyme form of vitamin B12, cyanocobalamin.⁵¹

Vitamin D
Vitamin D is a fat-soluble vitamin that plays a pivotal role in maintaining health.⁵² Vitamin D assists the absorption of calcium and phosphorus in the intestines and is important during periods of growth as it plays a critical role in bone mineralization.^53,54 While the majority of individuals may be deficient in Vitamin D, several groups are at high risk for vitamin D deficiency, including overweight individuals.^55,56 Supplementation in these groups is, therefore, especially important. A healthy diet with adequate calcium and vitamin D, and regular physical activity, helps to achieve strong bones and may reduce the risk of osteoporosis.⁸

Vitamin E
Vitamin E is a fat-soluble vitamin, best known for its major function as an antioxidant that prevents the formation of free radicals and repairs free radical cell damage.⁵⁷

Zinc
Zinc is an essential co-factor in a variety of cellular processes affecting reproduction, bone formation, growth, and wound healing. Zinc has been purported to play an important role in normal thyroid homeostasis. ^58,59,60

RECOMMENDED DOSAGE
Adults: 1 cap 2x/day with meals, a few hours before or after other medications.

CAUTIONS AND WARNINGS
For adult use only.

DISEASE/CONDITION INTERACTIONS
No statement.

DRUG INTERATIONS
No statement.

FORMULATION
Medicinal Ingredients:
Beta-Carotene .............................................. 825 mcg
Biotin .......................................................................... 18 mcg
Calcium (Calcium carbonate) ............................................ 50 mg
Chromium (Chromic dinicotinate) .................................. 22.5 mcg
Copper (Cupric gluconate) ............................................. 650 mcg
Folate (Folic acid) ......................................................... 240 mcg
Iodine (Kelp) .................................................................150 mcg
Magnesium (Magnesium oxide) ......................................... 25 mg
Manganese (Manganese [II] sulfate) ................................ 1.3 mg
Molybdenum (Sodium molybdate) .................................... 25 mcg
Niacinamide ...................................................................... 9.27 mg
Pantothenic acid (Calcium-d-pantothenate) ....................... 4 mg
Riboflavin ....................................................................... 0.96 mg
Selenium (Selenomethionine) .......................................... 35 mcg
Thiamine (Thiamine hydrochloride) .................................. 0.75 mg
Vitamin B6 (Pyridoxine hydrochloride) ................................. 1.08 mg
Vitamin B12 (Methylcobalamin) ....................................... 60 mcg
Vitamin C (Ascorbic acid) .................................................. 63 mg
Vitamin D (Cholecalciferol) ................................... 6 mcg / 240 IU
Vitamin E (D-α-Tocopheryl succinate) …............. 6.7 mg AT/ 10 IU
Zinc (Zinc oxide) ................................................................ 6 mg

Non-medicinal Ingredients:
Hypromellose, magnesium stearate, microcrystalline cellulose.
Features:

Gluten Free
Dairy Free
Dye Free.

REFERENCES
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² Medline Plus. National Institutes of Health. Beta-carotene. 2012. Available at: http://www.nlm.nih.gov/medlineplus/druginfo/ natural/999.html. Accessed May 21, 2015.
³ Hinds TS. West WL, Knight EM. Cartenoids and retinoids: a review of research, clinical, and public helath applications. J Clin Pharmacol. 1997;37(7):551-8.
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⁷ Vondracek SF. (2010). Managing Osteoporosis in postmenopausal women. Am J Health Syst Pharm. 67.7:S9- S19.
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