NPN: 80077803

Gives your body essential nutrition and helps maintain the body's ability to metabolize nutrients.

This multivitamin/mineral is essential for those undergoing weight loss to support overall health as it provides oxygen and energy to cells for optimal function. It ensures the prevention of nutritional deficiencies, that can sometimes accompany a calorie reduced diet. Foundation Multi gives the body essential nutrition, it also includes chromium to support healthy blood glucose levels. Finally, it includes iodine to help maintain a healthy thyroid, the gland responsible for metabolism and preventing the accumulation of body fat.

PRODUCT MONOGRAPH FOR HERBAL MAGIC
Foundation Multi NPN 80077803

GENERAL INFORMATION
Herbal Magic’s Foundation Multi is a multi-vitamin/mineral formula which contains a blend of vitamins and minerals designed to help meet the nutritional needs of today. Vitamins by definition are dietary substances required for good health and normal development, by regulating metabolism and assisting in all biochemical processes in the body. Their functions can be quite complex wherein any particular vitamin may have various metabolic and chemical roles. Minerals, like vitamins, act as co-enzymes enabling the body to perform its functions including energy production, growth and healing.

Foundation Multi is a fundamental comprehensive multi-vitamin/mineral designed to fill potential nutritional gaps and support successful weight management.

This daily multivitamin helps to:

Ensure the body is functioning optimally

Ensure optimal intake of nutrients to prevent nutritional deficiencies

Maintain optimal blood sugar control to prevent hunger and even out appetite

RECOMMENDED USES
Primary Uses: Helps to maintain good health and maintain the body's ability to metabolize nutrients as well as giving the body essential nutrition.

MECHANISM OF ACTION
Research Suggests
Beta-Carotene
Beta-Carotene is a source of vitamin A that helps to maintain eyesight, skin, membranes, and immune function¹. Research suggests that beta-carotene has variety of functions to prevent certain cancers, heart disease, cataracts and age related macular degeneration. ^2,3

Biotin
Biotin is a water-soluble vitamin that plays an essential role in maintaining metabolic homeostasis. Biotin acts as a cofactor in gluconeogenesis, fatty acid synthesis and amino acid catabolism. ^4,5,6

Calcium
Calcium is the most common mineral in the body and plays a key role in a wide range of biologic functions. Calcium has an important role in building stronger and denser bones, and is also involved in neurotransmitter release and muscle contraction.⁷ Adequate calcium and vitamin D, with regular physical activity, help to achieve strong bones and may reduce the risk of osteoporosis.⁸

Calcium is well recognized to play an important role in modulating chronic disease risk.⁹ Many studies have identified strong inverse correlations between adiposity, body weight, and calcium intake, recommending calcium supplementation with weight loss or weight control programs.^10,11

Chromium
Chromium is an essential trace element and it is necessary for the efficient metabolism of carbohydrates, lipids and protein in the body. ^12,13 Chromium has been shown to be useful in its ability to support insulin, thereby assisting in healthy glucose metabolism. It is thought that chromium potentiates the action of insulin by increasing receptor numbers and increasing insulin binding to cells.¹⁴ Chromium deficiency may lead to health problems such as insulin resistance, elevated blood glucose levels, and increased risk for cardiovascular conditions and diabetes mellitus. ^12,13

Copper
Copper is an essential trace metal that plays an integral part in numerous critical enzyme processes affecting vital biological systems. Copper helps to produce and repair connective tissue, and aids in formation of red blood cells. ^15,16

Folic acid
Folate, also known as folic acid, plays a vital role in DNA synthesis and amino acid metabolism. Folic acid is important for normal brain functions and cognition.c^17,18 Research suggests that supplementation of multivitamins containing folic acid during pre-pregnancy and pregnancy is associated with reduced risk of neural tube defects and preeclampsia. ^19,20 Also, Folic acid is important for normal fetal brain function and cognition.²¹

Iodine
Iodine is the trace element that has the greatest influence on thyroid function. Iodine is an integral constituent of thyroid hormones and is required for thyroid hormone homeostasis. Thyroid hormones are necessary for human life and proper thyroid status also depends on many trace elements. The thyroid produces hormones that affect the body's metabolism and energy level. ^22,23,24,25

Magnesium
Magnesium is critical to normal human homeostasis playing many roles in energy metabolism: as an enzyme cofactor, in electrolyte balance, and in the maintenance of the properties of various cell membranes. As one of the four most abundant cations in the body, magnesium is present in more than 300 enzymatic systems. ^29,30 Magnesium helps the body to metabolize carbohydrates, fats and proteins. Magnesium also plays an important role in maintaining muscle function and in the absorption of calcium. ^29,30

Manganese
Manganese is an essential trace nutrient that plays a role in various physiological processes. Manganese is required for the regulation of carbohydrate and lipid metabolism, reproduction and normal brain function. Manganese is also an important co-factor in the brain for several enzymes, such as the antioxidant enzyme superoxide dismutase and is involved in neurotransmitter synthesis and metabolism.³¹ Manganese may also affect thyroid hormone homeostasis.³²

Molybdenum
Molybdenum is considered an essential element in the human body. It is crucial for the functioning of several enzymes including sulfite oxidase, xanthine oxidase, and aldehyde oxidase.³³

Niacinamide
Niacinamide is an essential organic compound for metabolism, essential for energy production from carbohydrates, fatty acids, and amino acids.³⁴ Niacinamide is necessary for a variety of diverse biological processes including energy production and acts as an antioxidant.³⁵

Pantothenic acid
Pantothenic acid is involved in the metabolism of carbohydrates, proteins and lipids and is a component of coenzyme A, a molecule necessary for many vital chemical reactions to occur in cells.^{36, 37}

Riboflavin
Riboflavin is a water-soluble vitamin, important for human metabolism, protecting against cancer and cardiovascular disease. The body requires more riboflavin in cases of increased metabolic demand such as during weight loss or in periods of high stress. In such cases, the supply may be rapidly depleted so it is important to ensure frequent and sufficient replenishing of this essential vitamin. ^38,39

Selenium
The essential micronutrient selenium plays an important role in maintaining the equilibrium of a healthy organism, affecting optimal endocrine and immune function, and moderating the inflammatory response. Selenium exerts its biological effects mainly through enzymatically active selenoproteins which provide protection against lipid peroxidation, support thyroid hormone metabolism, T cell immunity and modulation of the inflammatory response.^40,41 Research findings link low selenium status to neurodegenerative and cardiovascular diseases.^42,43 Additionally, selenium may also support cardiovascular health by reducing the oxidation of LDL (“bad”) cholesterol in the body.

Thiamine
Thiamine is a water-soluble vitamin, essential in metabolic energy production and the metabolism of fats, carbohydrates and proteins. As humans are unable to synthesize thiamine, this vitamin must be obtained from exogenously. The body requires more thiamine in cases of increased metabolic demand such as weight loss. In such cases, the supply may be rapidly depleted so it is important to ensure frequent and adequate supply of this essential vitamin. ^44,45

Vitamin B6
Vitamin B6 acts as cofactor in more than 140 different enzyme reactions and has critical functions in cellular metabolism and stress responses. It is a potent antioxidant that effectively quenches reactive oxygen species and is thus of high importance for cellular health. ^46,47,48

Vitamin B12
Vitamin B12 aids in the formation and regeneration of red blood cells, thereby preventing anemia. Vitamin B12 promotes growth and is essential for the maintenance of a healthy nervous system. Vitamin B12 supports normal DNA synthesis, promotes growth⁴⁹, and also assists in the proper utilization of fats, carbohydrates and proteins. ^36,50 Evidence suggests that methylcobalamin is absorbed more efficiently than the other co-enzyme form of vitamin B12, cyanocobalamin.⁵¹

Vitamin D
Vitamin D is a fat-soluble vitamin that plays a pivotal role in maintaining health.⁵² Vitamin D assists the absorption of calcium and phosphorus in the intestines and is important during periods of growth as it plays a critical role in bone mineralization.^53,54 While the majority of individuals may be deficient in Vitamin D, several groups are at high risk for vitamin D deficiency, including overweight individuals.^55,56 Supplementation in these groups is, therefore, especially important. A healthy diet with adequate calcium and vitamin D, and regular physical activity, helps to achieve strong bones and may reduce the risk of osteoporosis.⁸

Vitamin E
Vitamin E is a fat-soluble vitamin, best known for its major function as an antioxidant that prevents the formation of free radicals and repairs free radical cell damage.⁵⁷

Zinc
Zinc is an essential co-factor in a variety of cellular processes affecting reproduction, bone formation, growth, and wound healing. Zinc has been purported to play an important role in normal thyroid homeostasis. ^58,59,60

RECOMMENDED DOSAGE
Adults: 1 cap 2x/day with meals, a few hours before or after other medications.

CAUTIONS AND WARNINGS
For adult use only.

DISEASE/CONDITION INTERACTIONS
No statement.

DRUG INTERATIONS
No statement.

FORMULATION
Medicinal Ingredients:
Beta-Carotene .............................................. 825 mcg
Biotin .......................................................................... 18 mcg
Calcium (Calcium carbonate) ............................................ 50 mg
Chromium (Chromic dinicotinate) .................................. 22.5 mcg
Copper (Cupric gluconate) ............................................. 650 mcg
Folate (Folic acid) ......................................................... 240 mcg
Iodine (Kelp) .................................................................150 mcg
Magnesium (Magnesium oxide) ......................................... 25 mg
Manganese (Manganese [II] sulfate) ................................ 1.3 mg
Molybdenum (Sodium molybdate) .................................... 25 mcg
Niacinamide ...................................................................... 9.27 mg
Pantothenic acid (Calcium-d-pantothenate) ....................... 4 mg
Riboflavin ....................................................................... 0.96 mg
Selenium (Selenomethionine) .......................................... 35 mcg
Thiamine (Thiamine hydrochloride) .................................. 0.75 mg
Vitamin B6 (Pyridoxine hydrochloride) ................................. 1.08 mg
Vitamin B12 (Methylcobalamin) ....................................... 60 mcg
Vitamin C (Ascorbic acid) .................................................. 63 mg
Vitamin D (Cholecalciferol) ................................... 6 mcg / 240 IU
Vitamin E (D-α-Tocopheryl succinate) …............. 6.7 mg AT/ 10 IU
Zinc (Zinc oxide) ................................................................ 6 mg

Non-medicinal Ingredients:
Hypromellose, magnesium stearate, microcrystalline cellulose.
Features:

Gluten Free
Dairy Free
Dye Free.

REFERENCES
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² Medline Plus. National Institutes of Health. Beta-carotene. 2012. Available at: http://www.nlm.nih.gov/medlineplus/druginfo/ natural/999.html. Accessed May 21, 2015.
³ Hinds TS. West WL, Knight EM. Cartenoids and retinoids: a review of research, clinical, and public helath applications. J Clin Pharmacol. 1997;37(7):551-8.
⁴ Zempleni J, Wijeratne SS, Hassan YI. Biotin. Biofactors. 2009;35(1):36-46.
⁵ Health Canada. Natural Health Products Directorate. Product Monographs. Biotin. 2007. Available at: http://webprod.hc-sc.gc.ca/nhpid-bdipsn/monoReq.do?id=41&lang=eng. Accessed May 21, 2015.
⁶ Gravel RA, Narang MA. Molecular genetics of biotin metabolism: old vitamin, new science. J Nutr Biochem. 2005;16(7):428-31.
⁷ Vondracek SF. (2010). Managing Osteoporosis in postmenopausal women. Am J Health Syst Pharm. 67.7:S9- S19.
⁸ L'Abbe MR, Whiting SJ, Hanley DA. The Canadian health claim for calcium, vitamin D and osteoporosis. J Am Coll Nutr. 2004; 23:303-8.
⁹ Moe Sharon. Disorders Involving Calcium, Phosphorus, and Magnesium. Prim Care. 2008;35(2): 215–vi.
¹⁰ Zemel MB, Shi H, Greer B, et al. Regulation of adiposity by dietary calcium. FASEB J. 2000;14(9):1132-8.
¹¹ Davies KM, Heaney RP, Recker RR et al. Calcium intake and body weight. J Clin Endocrinol Metab. 2000; 85(12):4635-8.
¹² National Institutes of Health. Dietary Supplement Fact Sheet: Chromium.
http://ods.od.nih.gov/factsheets/ChromiumHealthProfessional
¹³ Anderson, R.A. (2000). Chromium in the prevention and
control of diabetes. Diabetes Metab, 26(1): 22-27.
¹⁴ Cefalu WT, Frank B. Role of Chromium in Human Health and in Diabetes. Diabetes Care. 2004;27(11):2741.
¹⁵ Health Canada. Natural Health Products Directorate. Product Monographs. Copper. 2007. Available at: www.hc-sc.gc.ca Accessed Jan 5, 2011.
¹⁶ Gaetke L.M, Chow CK. Copper toxicity, oxidative stress, and antioxidant nutrients, Toxicology. 2003;189(1-2):147-63.
¹⁷ Selhub J, Jacques PF, Bostom AG, et al. Relationship between plasma homocysteine and vitamin status in the Framingham study population. Impact of folic acid fortification. Public Health Rev. 2000;28(1-4):117-45.
¹⁸ Fishman SM, Christian P, West KP. The role of vitamins in the prevention and control of anaemia. Public Health Nutr. 2000;3(2):125-50.
¹⁹ Crider Krista, Folic Acid Fortification-Its History, Effect, Concerns, and Future Directions. Nutrients. 2011;3(3): 370-384.
²⁰ Wen Shi, Folic acid supplementation in early second trimester and the risk of preeclampsia, American Journal of Obstetrics & Gynecology, 2006;198(1): 45-47.
²¹ Zaisel, Steven. The Fetal Orgins of memory: The Role of Dietary Choline In Optimal Brain Development. J Pediart. 2006;149(5)131-136.
²² Arthur JA. Beckett GJ. Thyroid function. British Medical Bulletin. 1999;55(3):658-68.
²³ Triggiani V, Tafaro E, Giagulli VA, et al. Role of iodine, selenium and other micronutrients in thyroid function and disorders. Endocr Metab Immune Disord Drug Targets. 2009;9(3):277-94.
²⁴ Hess SY. The impact of common micronutrient deficiencies on iodine and thyroid metabolism: the evidence from human studies. Best Pract Res Clin Endocrinol Metab. 2010;24(1):117-32.
²⁵ Patrick L. Iodine: deficiency and therapeutic considerations. Altern Med Rev. 2008;13(2):116-27.
²⁶ Lieu PT, Heiskala M, Peterson PA, et al. The roles of iron in health and disease. Mol Aspects Med. 2001;22(1-2):1-87.
²⁷ Nadadur SS, Srirama K, Mudipalli A. Iron transport & homeostasis mechanisms: their role in health & disease. Indian J Med Res. 2008;128(4):533-44.
²⁸ National Institutes of Health. Dietary Supplement Fact Sheet: Iron. http://ods.od.nih.gov/factsheets/IronHealthProfessional.
²⁹ Health Canada. Natural Health Products Directorate. Product Monographs. Magnesium. 2007. Available at: http://webprod.hc-sc.gc.ca/nhpid-bdipsn/monoReq.do?id=135&lang=eng. Accessed May 21, 2015.
³⁰ Fox C, Ramsoomair D, Carter C. Magnesium: Its Proven and Potential Clinical Significance. South Med J. 2001; 94(12).
³¹ Bagga S, Levy L. Overview of Research into the Health Effects of Manganese (2002-2007) Report, Institute of Environment and Health for the Manganese Health Research Program (MHRP), Institute of Environment and Health, Cranfield University. Available at http://www.manganese-health.org/Overview_of_Research_into_the_Health_Effects_of_Manganese.pdf. Accessed May 21, 2015.
³² Soldin OP, Aschner M.Effects of manganese on thyroid hormone homeostasis: potential links. Neurotoxicology. 2007;28(5): 951-6.
³³ Novotny JA, Turnlund JR. Molybdenum intake influences molybdenum kinetics in men. J Nutr. 2007;137(1):37-42.
³⁴ Health Canada. Natural Health Products Directorate. Product Monographs. Niacinamide 2009. Available at http://webprod.hc-sc.gc.ca/nhpid-bdipsn/monoReq.do?id=142&lang=eng. Accessed May 21, 2015.
³⁵ Bogan KL, Brenner C. Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition. Annu Rev Nutr. 2008;28:115-30.
³⁶ Picciano MF, Pregnancy and lactation: physiological adjustments, nutritional requirements and the role of dietary supplements. J. Nutr. 2003;133(6): 1997S-2002S.
³⁷ Health Canada. Natural Health Products Directorate. Product Monographs. Pantothenic Acid 2007. Available at: www.hc-sc.gc.ca Accessed May 21, 2015.
³⁸ Powers HJ. Riboflavin (vitamin B-2) and health. Am J Clin Nutr. 2003;77(6):1352-60.
³⁹ Woolf K, Manore MM. B-vitamins and exercise: does exercise alter requirements? Int J Sport Nutr Exerc Metab. 2006; 16(5):453-84.
⁴⁰ Ashton K, Hooper L, Harvey LJ, et al. Methods of assessment of selenium status in humans: a systematic review. Am J Clin Nutr. 2009 Jun;89(6):2025S-2039S. Epub 2009 May 6.
⁴¹ Combs GF, Midthune DN, Patterson KY, et al. Effects of selenomethionine supplementation on selenium status and thyroid hormone concentrations in healthy adults. Am J Clin Nutr. 2009;89:1808–14.
⁴² Brenneisen P, Steinbrenner H, Sies H Selenium, oxidative stress, and health aspects. Mol Aspects Med. 2005 Aug-Oct;26(4-5):256-67.
⁴³ Rayman MP, Rayman MP. The argument for increasing selenium intake. Proc Nutr Soc. 2002 May;61(2):203-15.
⁴⁴ Gagnolf M, Czerniecki J, Radermecker M. Thiamine Status in Humans and Content of Phosphorylated Thiamine Derivatives in Biopsies and Cultured Cells. PLoS ONE. 2010;5:10, e13616.
⁴⁵ Singleton CK, Martin PR. Molecular mechanisms of thiamine utilization. Curr Mol Med. 2001;1(2):197-207.
⁴⁶ di Salvo ML, Contestabile R, Safo MK. Vitamin B(6) salvage enzymes: Mechanism, structure and regulation. Biochim Biophys Acta. 2010;[Epub ahead of print].
⁴⁷ Mooney S, Leuendorf JE, Hendrickson C, et al. Vitamin B6: a long known compound of surprising complexity. Molecules. 2009;14(1):329-51.
⁴⁸ Health Canada. Natural Health Products Directorate. Product Monographs. Pyroxidine-5-phosphate. 2007. Available at: www.hc-sc.gc.ca Accessed May 21, 2015.
⁴⁹ IOM 1998: Institute of Medicine. Panel on Folate, other B Vitamins, and Choline and Subcommittee on Upper Reference Levels of Nutrients, and the Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin and Choline. National Academy Press.
⁵⁰ Health Canada. Natural Health Products Directorate. Product Monographs. Cyanocobalamin. 2007. Available at: www.hc-sc.gc.ca. Accessed May 21, 2015.
⁵¹ Okuda K, Yashima K, Kitazaki T, Takara I. Intestinal absorption and concurrent chemical changes of methylcobalamin. J Lab Clin Med 1973;81:557-567.
⁵² Planton J, Meyer JO, Edlund BJ. Vitamin d. J Gerontol Nurs. 2011;37(1):9-13.
⁵³ Health Canada. Natural Health Products Directorate. Product Monographs.Vitamin D. 2007. Available at: www.hc-sc.gc.ca Accessed May 21, 2015.
⁵⁴ Rabovsky BA, Komarov AM, Ivie JS, Minimization of free radical damage by metalcatalysis of multivitamin/multimineral supplements. Nutrition Journal. 2010;9:61.
⁵⁵ Caan B, Neuhouser M, Aragak A, et al. Calcium Plus Vitamin D Supplementation and the Risk of Postmenopausal Weight Gain. Arch Intern Med. 2007;167(9):893-902.
⁵⁶ De-Regil Luz, Palacios Cristina, Ansary Ali, et al. Vitamin D supplementation for women during pregnancy. Cochrane Database of Systematic Reviews, 2012;Issue 2.
⁵⁷ Herrera E, Barbas C. Vitamin E: action, metabolism and perspectives. J Physiol Biochem. 2001;57(1):43-56.)( Mustacich DJ, Bruno RS, Traber MG. Vitamin E. Vitam Horm. 2007;76:1-21.
⁵⁸ Ertek S, Cicero AF, Caglar O, Erdogan G. Relationship between serum zinc levels, thyroid hormones and thyroid volume following successful iodine supplementation. Hormones (Athens). 2010;9(3):263-8.
⁵⁹ Health Canada. Natural Health Products Directorate. Product Monographs. Zinc. 2007. Available at: www.hc-sc.gc.ca Accessed May 21, 2015.
⁶⁰ Barceloux DG. Zinc. J Toxicol Clin Toxicol. 1999;37(2):279-92.

RECOMMENDED DOSAGE
Adults: 1 cap 2x/day with meals, a few hours before or after other medications.

CAUTIONS AND WARNINGS
For adult use only.

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