NPN: 80034047

Manage weight along with exercise and a calorie-reduced diet.

Lean Extreme can be useful for those seeking a supplement aid to help them in their weight loss efforts, those experiencing slowed weight loss or weight loss plateaus as it boosts metabolism to get you back on track, or those who want to maintain a healthy BMI and weight after weight reduction.

When Lean Extreme is used with the Herbal Magic program, it is even more effective as it helps achieve and maintain your weight loss goal.

PRODUCT MONOGRAPH FOR HERBAL MAGIC
LEAN EXTREME NPN 80034047

GENERAL INFORMATION
Herbal Magic’s Lean Extreme^TM is designed to complement an exercise regimen for individuals on a weight management program with reduced caloric intake.
Research on the components of Lean Extreme^TM demonstrate they are an excellent source of antioxidants which help with the maintenance of good health and weight management and support plasma glutamine levels to help with muscle cell repair after exercise. ^1,2

RECOMMENDED USES
Primary Use: To be used with a program of reduced intake of dietary calories and increased physical activity (if possible) to help in weight management.

MECHANISM OF ACTION
Research Suggests
Camellia sinesis (Green tea Leaf Extract)
Camellia sinensis (green tea leaf extract), contains an epigallo catechin gallate (EGCG) caffeine mixture. This EGCG caffeine mixture is an excellent source of antioxidants which help with the maintenance of good health and weight management.^3,4 Many human studies have demonstrated the positive effect of green tea on weight management.^5,6,7,8,9 Research also indicates that green tea suppresses appetite and decreases energy intake.¹⁰ Additionally, green tea catechin supplements and caffeine have been demonstrated to have a positive effect on blood glucose levels.^11,12

It has been proposed that green tea is able to exert effects on weight management through a synergistic effect of both EGCG and caffeine on thermogenesis, fat oxidation, and sparing fat free mass during weight maintenance.¹³ Even though caffeine has been shown to promote weight management the effect of caffeine with EGCG present in green tea, has been shown to have a greater effect than caffeine alone on weight management.¹⁴ As a result, the use of caffeine independent of green tea does not have the same effects on 24-hour energy expenditure or fat oxidation. ¹⁵

Green Tea, when used in the ratio of 15% EGCG to 8.3% caffeine for an average of 12 weeks, demonstrates a positive effect on weight management.^16,17,18

Green tea is also thought to confer cardiovascular protection by decreasing LDL cholesterol and triglycerides as well as by blocking platelet aggregation.^19,20

L-glutamine
L-glutamine is an amino acid produced primarily in skeletal muscle. Although classified as a non-essential amino acid, L-glutamine is essential for maintaining intestinal function, immune response, and amino acid homeostasis during times of stress, and thus is often called a conditionally essential amino acid. L-glutamine is released into circulation when required, particularly in times of metabolic stress. When the body is experiencing physical stress, the body may consume more glutamine than the skeletal muscle can produce. Progressive muscle breakdown (wasting) can occur as the body tries to meet glutamine requirements.^21,22,23 As a result, muscle function can decline as progressive muscle breakdown occurs. Supplementation of L-glutamine has been shown to be beneficial to enhance exercise performance.^24,25,26,27

In general, L-glutamine helps support digestive system health after periods of physical stress, is linked to energy metabolism and physical activity, and is important in sustaining immune function.^20,28,29,30 L-glutamine has also been found to increase carbohydrate oxidation and promote meal related energy expenditure. L-glutamine has been found to increase post-meal energy expenditure by increasing post-meal carbohydrate oxidation and fat oxidation.³¹ Preliminary evidence proposed L-glutamine supplementation may prevent hyperglycemia and hyperinsulinemia, suggesting it to be a useful in increasing insulin sensitivity.³²

RECOMMENDED DOSAGE
Adults: For oral use only. Take 3 to 6 capsules daily with food or as directed by your health care practitioner. Consult a health care practitioner for use beyond 12 weeks.

CAUTIONS AND WARNINGS
For adult use only. Consult a health care practitioner prior to use if you are pregnant or breastfeeding.

DISEASE/CONDITION INTERACTIONS
Consult a health care practitioner prior to use if you have a liver disorder or develop symptoms of liver trouble (such as abdominal pain, dark urine, or jaundice). Consult a health care practitioner prior to use if you have an iron deficiency. Consult a health care practitioner prior to use if you follow a low protein diet.

FORMULATION
Medicinal Ingredients:
Caffeine………………………………..22mg
Green tea leaf extract (12:1) [Camellia sinensis, 46% EGCG (epigallocatechin gallate, 3% caffeine, 75% catechins)]
Provides 46 mg EGCG, 3 mg caffeine & 75 mg
Catechins…..................................100 mg (1200 mg crude/brut)
L-glutamine…………………………...100 mg

Non-medicinal Ingredients:
Cellulose, hydroxypropyl methylcellulose, magnesium searate and silica.

REFERENCE
¹ Health Canada. Natural Health Products Directorate. Product Monographs. Green Tea. 2008. Available at: www.hc-sc.gc.ca Accessed Jan 31, 2011.
² Health Canada. Natural Health Products Directorate. Product Monographs. Glutamine. Available at: www.hc-sc.gc.ca Accessed Jan 31, 2011.
³ Yanagida A, Shoji A, Shibusawa Y, et al. Analytical separation of tea catechins and food-related polyphenols by high-speed counter-current chromatography. J Chromatogr A. 2006;1112(1-2):195-201.
⁴ Nagle DG, Ferreira D, Zhou YD. Epigallocatechin-3-gallate (EGCG): chemical and biomedical perspectives. Phytochemistry. 2006;67(17):1849-55.
⁵ Hursel R, Viechtbauer W, Westerterp-Plantegna MS. The effect of green tea on weight loss and weight maintenance:A Meta-analysis. Int J Obes (Lond). 2009;33(9):956-61.
⁶ Wolfram S. Effects of Green Tea and EGCG on Cardiovascular and Metabolic Health. J Am Nutr. 2007;26(4):373S-388S
⁷ Zheng G, Sayama K, Okubo T, et al. Anti-obesity effects of three major components of gr een tea, catechins, caffeine and theanine, in mice. In Vivo. 2004;18(1):55-62.
⁸ Phung OJ, Baker WL, Matthews LJ, et al. Effect of green tea catechins with or without caffeine on anthropometric measures: a systemic review and meta-analysis. Am J Clin Nutr. 2010;91(1):73-81.
⁹ Basu A, Sanchez K, Leyva MJ, et al. Green tea supplementation affects body weight, lipids, and lipid peroxidation in obese subjects with metabolic syndrome. J Am Coll Nutr. 2010;29(1):31-40.
¹⁰ Reinbach HC, Smeets A, Martinussen T, et al. Effects of capsaicin, green tea, and CH-19 sweet pepper on appetite and energy intake in humans in negative and positive energy balance. Clin Nutr. 2009;28(3):260-5.
¹¹ Petrie HJ, Chown SE, Belfie LM, et al. Caffeine ingestion increases the insulin response to an oral-glucose-tolerance test in obese men before and after weight loss. Am J Clin Nutr. 2004;80(1):22-8.
¹² Hase T, Komine Y, Meguro S, et al. Anti-obesity effects of Tea Catechins in Humans. J Oleo Sci. 2001;50(7):599-605.
¹³ Westerterp-Plantenga MS. Green tea catechins, caffeine and body-weight regulation. Physiol Behav. 2010;100(1):42-6.
¹⁴ Diepvens K, Westerterp K, Westerterp-Plantenga MS. Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea. Am J Physiol Reg Integr Comp Physiol. 2007;292(1):R77-85
¹⁵ Dulloo AG, Duret C, Rohrer D, et al. Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. Am J Clin Nutr. 1999;70:1040-5
¹⁶ Nagao T, Komine Y, Soga S, et al. Ingestion of a tea rich in catechins leads to a reduction in body fat and malondialdehyde-modified LDL in men. Am J Clin Nutr. 2005;81(1):122-9.
¹⁷ Westerterp-Plantenga MS, Lejeune MP, Kovacs EM. Body weight loss and weight maintenance in relation to habitual caffeine intake and green tea supplementation. Obes Res. 2005;13(7):1195-204.
¹⁸ Chantre P, Lairon D. Recent findings of green tea extract AR25 (Exolise) and its activity for the treatment of obesity. Phytomedicine. 2002;9(1):3-8
¹⁹ Maron DJ, Lu GP, Cai NS, et al. Cholesterol-lowering effect of a theaflavin-enriched green tea extract: a randomized controlled trial. Arch Intern Med. 2003;163(12):1448-53.
²⁰ Jin YR, Im JH, Park ES, et al. Antiplatelet activity of epigallocatechin gallate is mediated by the inhibition of
PLCgamma2 phosphorylation, elevation of PGD2 production, and maintaining calcium-ATPase activity. J Cardiovasc Pharmacol. 2008;51(1):45-54.
²¹ Newsholme P, Procopio J, Lima MM, Pithon-Curi TC, Curi R. Glutamine and glutamate-their central role in cell metabolism and function. Cell Biochemistry and Function. 2003;21(1):1-9.
²² Holecek M. Relation between glutamine, branched-chain amino acids, and protein metabolism. Nutrition. 2002;18:130-3
²³ Bowtell JL, Gelly K, Jackman ML, et al. Effect of oral glutamine on whole body carbohydrate storage during recovery from exhaustive exercise. Journal of Applied Physiology. 1999;86(6):1770
²⁴ Carvalho-Peixoto J, Alves R, Cameron LC. Glutamine and Carbohyrate supplements reduce ammonemia increase during endurance field exercise. Appl Physiol Nutri Metab. 2007;32:1186-90.
²⁵ Castell L. Can glutamine modify the apparent immunodepression observed after prolonged, exhaustive evidence? Nutrition. 2002;18(5):371-5.
²⁶ Castell L. Glutamine supplementation in vitro and in vivo, in exercise and in immunodepression. Sports Med. 2003;33(5):323-45.
²⁷ Hoffman J, Ratamess N, Kang J, et al. Examination of the efficacy of acute L-alanyl-L-glutamine ingestion during hydration stress in endurance exercise. Journal of International Society of Sports Nutrition. 2010;7:8.
²⁸ Agostini F, Biolo G. Effect of physical activity on glutamine metabolism. Curr Opin Clin Nut Metab Care. 2010;13(1):58-64.
²⁹ Newsholme P. Why is L-glutamine metabolism important to cells of the immune system in health, postinjury, surgery or infection? J Nutr. 2001;131:2515S-22S.
³⁰ Castell LM, Newsholme EA. The effects of oral glutamine supplementation on athletes after prolonged, exhaustive exercise. Nutrition. 1997;13(7-8):738-42
³¹ Iwashita S, Mikus C, Baier S. Glutamine Supplementation Increases postprandial energy expenditure and fat oxidation in humans. J Parenter Enteral Nutri. 2006;30(2):76-80.
³² Mauras N, Dongyuan X, Fox L. Effects of Glutamine on Glyzemic Control During and After Exercise in Adolescents with Type 1 Diabetes. A pilot study. Diabetes Care. 2010;33(9):1951-53.

RECOMMENDED DOSAGE
Adults: For oral use only. Take 3 to 6 capsules daily with food or as directed by your health care practitioner. Consult a health care practitioner for use beyond 12 weeks.

CAUTIONS AND WARNINGS
For adult use only. Consult a health care practitioner prior to use if you are pregnant or breastfeeding.

DISEASE/CONDITION INTERACTIONS
Consult a health care practitioner prior to use if you have a liver disorder or develop symptoms of liver trouble (such as abdominal pain, dark urine, or jaundice). Consult a health care practitioner prior to use if you have an iron deficiency. Consult a health care practitioner prior to use if you follow a low protein diet.

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